The Thursday crash, which occurred shortly after noon, shut down part of the roadway from Stowe to Morrisville for at least eight hours, the Burlington Free Press reported.
A 2005 Honda Civic driven by Eugeniusz Adamczyk, 72, pulled out onto Vermont 100 from Randolph Road and was struck by a tractor trailer traveling north, an investigation found.
The truck was a Western Star with a tandem trailer attached carrying wood logs.
Adamczyk and his passenger, Alfreda Adamczyk, 63, were pronounced dead at the scene.
The tractor trailer was driven by Arnold Withers, 67, of Danville. He was not injured, Stowe police Chief Donald Hull said.
Police are continuing to investigate the cause. Part of that investigation involves determining whether the three people involved were wearing their seat belts, Hull said.
Police urge those who witnessed the crash or have additional information to contact Stowe Police Department at 253-7126.